ACT 0
It is just a beginning
There are a huge number of databases and tools used in molecular biology and bioinformatics. But there are a few that are the most important and basic among them.
Here you will meet the NCBI, BLAST and the ancient Alpine wanderer.
We invite you to get acquainted with them.
Not all DNA is transcribed into RNA, and not all RNA is translated into proteins. At the very least, an open reading frame must exist in the RNA molecule in order for protein synthesis to begin.
Try to find order in chaos and read hidden messages.
ACT 1
Exploring the past in the trees
Phylogenetic analysis is the study of the evolutionary development of a species or a group of organisms or a particular characteristic of an organism, like a gene or protein. Several approaches are used in such analysis, like multiple sequence alignment and phylogenetic tree reconstruction.
A phylogenetic tree is a graphical representation of evolutionary origin of different species, organisms, or genes from a common ancestor.
Let's climb this tree.
Our genome contains only a few percent of protein-coding sequences; the vast majority of it is occupied by non-coding and regulatory sequences. And their phylogenetic analysis is a non-trivial and very complex task.
But let's try to understand the evolution of such sequences and build a phylogenetic tree for them too.
Find what's hidden in the tree crowns.
The year of 2019 gave us the perfect object to study in the light of evolution. The SARS-CoV-2 coronavirus outbreak, first reported in Wuhan province in China in December 2019, has resulted in a pandemic affecting 213 countries and territories worldwide.
The virus spreads very quickly and, walking through the human population, constantly changes, giving rise to new strains, sometimes with new properties and requiring a different approach to treatment.
Let's hunt down the new strains.
ACT 2
Put the splinters back together
Gene expression is the process by which the information encoded in a gene is converted into a function. It can vary greatly in different cells and depends on both external and internal signals.
Make an express analysis of expression
ACT 4
The deepest circle
Here you will need to make your own homology search and the phylogenetic analysis for a chosen gene.
It's the final boss of this course.
Exploring Linux
Just try it
Make it serve you and relish the great power.
Everything you need to feel the power of Linux.
Dungeons Of Bioinformatics
Get the light of knowledge